Principal Scientist Upstream Process Development Lead - Pfizer, S.A. de C.V : Job Details

We're in relentless pursuit of breakthroughs that change patients' lives. We innovate every day to make the world a healthier place.

To fully realize Pfizer's purpose – Breakthroughs that change patients' lives – we have established a clear set of expectations regarding “what” we need to achieve for patients and “how” we will go about achieving those goals.

Pfizer Research & Development serves as the beating heart of Pfizer's trailblazing product pipeline, the essence of our mission to bring life-changing medicines to the world.

Pfizer offers competitive compensation and benefits programs designed to meet the diverse needs of our colleagues.

Role Overview: This laboratory-based role involves leading the development of advanced mammalian cell culture and bacterial fermentation processes for protein production in Vaccines Early Bioprocess Development (EBPD). The incumbent will oversee the design, planning, and execution of cell/bacterial culture process development experiments, requiring proven expertise in media optimization, recombinant protein expression, and upstream process development. Responsibilities include developing and optimizing media and upstream processes in bioreactors to improve growth, yield, and quality, with essential experience in AMBR250/bioreactor/WAVE systems. The role demands understanding of scale-up, GMP considerations, meticulous documentation, and effective data presentation, coupled with proven leadership skills.

Key Responsibilities:

Qualifications:

Must Have:

• Ph.D. in relevant fields with a minimum of 5 years industry experience, or MS with 9 years, or BS with 10 years of experience.
• Strong background in cell biology, biochemistry, biochemical engineering, and cell culture techniques, including high-throughput technology.
• Extensive experience with small and large-scale mammalian cell culture using bioreactors/WAVE.
• Experience with DOE and statistical data analysis.
• Knowledge of QbD principles and process development.

Nice to Have:

• Experience with advanced technologies like perfusion, iCELLis, continuous processing.
• Expertise in media development, cell metabolism, big data analysis, and regulatory requirements.
• Experience with CMC drug development, tech transfer, PPQ/CPV, downstream purification, and protein characterization.

Physical and Mental Requirements:

• Ability to perform lab experiments safely, including standing, sitting, lifting, and bending.
• Capability of aseptic transfers, lifting up to 50 lbs, and performing equipment operations.
• Strong scientific judgment, data analysis skills, and detailed understanding of the subject matter.

Work Schedule and Other Details:

• May require irregular hours, including weekends.
• Relocation support available; on-premise work location.

Compensation and Benefits: Salary range from $102,900 to $171,500, with bonus potential and long-term incentives. Comprehensive benefits include retirement plans, paid leave, health coverage, and more. Details at Pfizer Candidate Site – U.S. Benefits.

Additional Notes: Relocation assistance may be provided. Pfizer complies with transparency laws regarding payments to healthcare providers and is committed to equal employment opportunity and work authorization requirements.