Principal Scientist, Translational Sciences - ZipRecruiter : Job Details

Job DescriptionJob DescriptionRepertoire Immune Medicines is a biotechnology company working to unlock and direct the remarkable power of the human immune system to treat cancer and autoimmune disease. The companywasfounded on the belief thatunderstandingthe repertoire of T cell receptor (TCR)-antigenimmune synapsesthat maintain health and drive disease represents one of the greatest opportunities for innovation in medical science. Repertoire scientists created and developed the DECODETMplatform, which allows in-depth characterization of TCR-antigen pairs, and the ability todeploy this information in the form ofnovel targeted immune medicinesto fundamentally reprogram the immune system to kill tumors or induce immune homeostasis.From its sites in Cambridge, Massachusetts and Zurich, Switzerland, Repertoire's team is advancing a pipeline of DECODE-enabled immune medicines. For cancer, we are developing a pipeline of TCR bispecifics molecules for treatment of multiple cancer types. Repertoire is progressing through IND-enabling studies with its lead development candidate and is planning to initiate a Phase 1/2 clinical trial in multiple cancer indications. In addition, we are developing a pipeline of mRNA tolerizing vaccines for treatment of autoimmune diseases.Repertoire was foundedin 2019 by Flagship Pioneering andis supported by a strong investor base. The company entered into a collaboration and license agreement with Genentech in April of 2025 to discover and develop innovative T cell-targeted immune medicines for an autoimmune indication. In addition, Repertoire entered a strategic partnership in April of 2024 with Bristol Myers Squibb to develop tolerizing vaccines for up to three autoimmune diseases.Principal Scientist, Translational Sciences (Oncology)We are seeking a highly motivated and experienced Principal Scientist in Translational Sciences that will be responsible for developing, implementing, and executing cross-functional activities to bridge preclinical and clinical development programs, across multiple therapeutic areas and drug modalities. A successful candidate will have a deep knowledge and focus on protein therapeutics, immune-oncology drug development, and genomic capabilities.Reporting to the Vice President, Project Lead and Head of Translational Medicine, this accomplished scientist will have deep expertise in biomarkers in oncology to lead the design, implementation, and oversight of biomarker strategies for Phase I clinical trials in solid tumors. The ideal candidate will have a strong background in circulating tumor DNA (ctDNA), genomic profiling, and immune/DNA-based assays, as well as hands-on experience managing biomarker vendors and ensuring high-quality execution of exploratory biomarker analyses.Key Responsibilities

• Design and execute translational biomarker strategies to support mechanism-of-action, PK/PD, dose predictions, and patient stratification in Phase I/II first-in-human oncology trials.
• Integrate preclinical and clinical data to generate hypotheses and guide data-driven decision-making in early development.
• Lead development and implementation of exploratory and translational biomarkers, including immune profiling, ctDNA, and genomic assays, with a strong understanding of solid tumor biology.
• Evaluate and oversee protein biomarker assays relevant to therapeutic response and resistance.
• Manage external vendors and CROs for biomarker assay development, sample testing, and data delivery; ensure high-quality execution and troubleshooting as needed.
• Oversee sample logistics (tumor tissue, liquid biopsies) to ensure integrity and timely analysis.
• Partner closely with Clinical Development and Discovery Research teams to ensure translational plans align with clinical objectives and regulatory strategies.
• Work closely with leadership to develop, manage, and deliver translational research timelines, budgets, metrics, and milestones.
• Demonstrate a strong work ethic and ability to work well in team environment.
• Communicate key findings and recommendations to senior leadership.

Qualifications

• PhD, MD, or equivalent in cancer biology, oncology, immunology, molecular biology, or related field.
• 8+ years of biotech/pharma experience in translational sciences or biomarker research, ideally in a biotech or pharmaceutical environment.
• Deep understanding of solid tumor biology, immune biomarkers, and ctDNA/genomic analysis, along with hands-on experience managing biomarker execution in early-phase clinical trials.
• Strong understanding of drug development for protein therapeutics and immune-oncology mechanisms.
• Demonstrated experience supporting Phase I/II first-in-patient clinical studies.
• Experience incorporating ctDNA endpoints into Phase I/II oncology clinical trials, including exploratory biomarker strategies and regulatory considerations.
• Experience transferring and overseeing assays at CROs or central labs.
• Working knowledge of pharmacokinetics (PK) and anti-drug antibody (ADA) assessments for protein therapeutics, and ability to integrate PK/ADA findings with biomarker and clinical data to guide early development decisions.
• Hands-on or oversight experience with circulating tumor DNA (ctDNA), including use in solid tumor clinical trials for patient stratification and treatment response monitoring.
• Entrepreneurial mindset, excellent communication skills, and passion for advancing new therapies for patients.

Repertoire is committed towards social responsibility and developing an inclusive culture. Much as the power of the immune system lies in the of T and B cells, our work requires the creativity and ingenuity of a diverse workforce. We believe in actively pursuing equity in all facets of the work experience at Repertoire. We will continue to educate ourselves about the inequities and barriers present in our society and take action as a company where we can make a difference.Repertoire is proud to be an Equal Opportunity Employer.Recruitment & Staffing Agencies: Repertoire Immune Medicines (“Repertoire”) does not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to Repertoire or its employees is strictly prohibited unless contacted directly by Repertoire's internal Human Resources team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of Repertoire, and Repertoire will not owe any referral or other fees with respect thereto.

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