Vivatides is an exciting start-up with opportunities to develop the next generation RNA therapeutics. We are seeking experienced scientists to lead our antibody-oligonucleotide conjugates (AOC) programs, focusing on siRNA and ASO payloads for targeted delivery. The ideal candidate will have a strong background in biologics and conjugates, playing a key role in expanding extrahepatic delivery of oligonucleotides through antibody conjugation. This leadership role offers the chance to shape cutting-edge therapeutics and impact our R&D pipeline.
Key Responsibilities
Design, generate, and optimize antibody-siRNA/ASO conjugates for targeted delivery.Coordinate antibody discovery, engineering, conjugation, and characterization workflows with CROs/CDMOs, external partners, or internal groups, ensuring high-quality, timely delivery for in vitro and in vivo studies.Develop assays to validate antibody and receptor targets and lead proof-of-concept studies with internal and external teams.Oversee QC and analytical characterization (e.g., DAR, purity, stability); work with CMC to establish SOPs for scale-up.Stay informed on the competitive landscape and emerging technologies in oligonucleotide delivery and antibody conjugates.Contribute to patent strategies, scientific publications, and regulatory documents.Drive drug discovery programs from inception to clinical development.Mentor junior scientists and support team growth.Qualifications
PhD in Biology, Biochemistry, Molecular Biology, Chemical Biology, Bioengineering, or related field with 8+ years of industry experience (or MS with 12+ years).Proven leadership in antibody-based drug development to clinical stages.Experience with ADC or AOC is highly preferred.Proficiency in antibody discovery, engineering, and developability.Experience in downstream processing and scale-up of antibody conjugates.Deep knowledge of bioconjugation techniques and linkers.Experience with biophysical, cell-based, and analytical assays, including LC-MS.Experience preparing IND documents and QC for regulatory submissions.Strong leadership skills, ability to manage collaborations and CRO relationships.Excellent communication skills and ability to work in a fast-paced startup environment; self-starter with troubleshooting skills.#J-18808-Ljbffr
